I would also like to point out i watched the dubbed version. I'm not one of the anime fans who has to have everything subbed, i tend to prefer dubbed as i find it easier to concentrate on what's happening. Also my other half has trouble reading the subs >.<
The first event i wanted to mention was the story of the little girl Nina Tucker who we meet very early one. Her father Shou Tucker, desperate not to lose his funding alchemically fused her with her pet dog Alexander.
The brothers become friends with her then return to find she has become a chimera, Ed and Al realize this but also understand they cannot help her, they report the incident to Colonel Mustang who labels the house as a crime scene, but before transport arrangements can be made, a serial killer by the name of Scar appears and kills them both, believing his killing of Nina/Alexander to be a mercy killing and prays for her soul. This is the first time (and certainly not the last) i cried my eyes out at and became emotionally attached to the series.